Downloads and Links
Directions to the venue
Site plan (showing car park)
It has been over twenty years since Lipinski published his work determining the properties of drug molecules associated with good solubility and permeability. Since then, there have been a number of additions and expansions to these “rules”. There has also been keen interest in the application of these guidelines in the drug discovery process and how these apply to new emerging chemical structures such as macrocycles.
This symposium will bring together researchers from a number of different areas of drug discovery and will provide a historical overview of the use of Lipinski’s rules, as well as looking to the future and how we use these rules in the changing drug compound landscape.
Features of the Meeting
Historical look at the use of the Rule of Five
New parameters used in drug discovery
Look forward to the next 20 years
Panel discussion in each session
Who should attend
This meeting is of interest to scientists of any level of experience from academia and industry.
Call for Poster Abstracts
Applications for poster presentations were invited within the theme of historical use of the Rule of Five or looking forward and beyond the Rule of Five. Posters will be displayed throughout the day. The closing dates for submissions were:
6th October - poster
30th June - oral.
|09:30||Registration and refreshments|
Session 1: History to Present Day
Session chair: Mary Wheldon, University of Dundee
The rule of five and the pursuit of compound quality
Paul Leeson, Paul Leeson Consulting, UK
Do we need to change the definition of drug-like properties?
Michael Shultz, Novartis, USA
|11:00||Refreshments and posters|
Molecule properties: how relevant are aromatic and aliphatic descriptors?
Tim Ritchie, Zerlavanz Consulting UK, UK
BET PROTACs: investigating the effects of linker functionality on physicochemical properties
John Priestner, GlaxoSmithKline, UK
Discussion panel, facilitated by Chris Swain, Cambridge MedChem Consulting
Lunch and posters
Session 2: Beyond the Rule of Five and the Future
Session chair: Jonathan Goodman, University of Cambridge
Structure property relationships in the Ro5 space and beyond
Elisabetta Chiarparin, AstraZeneca, UK
Investigating the chameleonic properties of αVβ6 integrin antagonists for the treatment of IPF
James Thompson, GlaxoSmithKline, UK
Chemical space adventures below and beyond Lipinski
Jean-Louis Reymond, University of Bern, Switzerland
Refreshments and posters
Defining known drug space using DFT
Jóhannes Reynisson, Keele University, UK
|16.30 ||Property-based drug design Beyond Ro5- lessons learned from AbbVie’s drugs and compound collection|
Phil Cox, AbbVie, USA
|17:00||Panel discussion, facilitated by Mihiro Sunose, Sygnature Discovery|
|17:30||Drinks reception |
Registration and Bursaries
Registration is now closed - fully booked
If you wish to add your name to a waiting list in case of additional spaces becoming available, please send an e-mail to Maggi via this link.
£120 RSC member
£50 RSC student* member
£80 Student* non-member
* Student is undergraduate or post-graduate, not post-doc
Member is a paid-up member of the RSC. A late fee of £30 will apply to payments received from 19th October onwards.
A number of RSC-BMCS and RSC-CICAG student bursaries were available up to a value of £250, to support registration, travel and accommodation costs for PhD and post-doctoral applicants studying at academic institutions. The closing date for bursary applications was 4th October.
Delegate Pack Inserts
Delegate pack inserts may be booked at £150, comprising no more than two pages of A4 fixed together.
In the event of cancellation before 6th November, 80% of the fee paid will be refunded. Cancellations must be received in writing. Refunds will not be possible from that date although substitutions are possible at any time.
In the unlikely event of cancellation of the meeting, fees paid will be refunded in full. Registration acknowledgements will be sent within two weeks.
Venue and Travel
Address: Innovation Building, Sygnature Discovery, BioCity, Pennyfoot Street, Nottingham NG1 1GF. Please download a site plan (showing car park) here.
East Midlands airport is just 20 minutes away, and regular trains run direct from London (journey time two hours). Sygnature Discovery is just over half-a-mile from the railway station.
Leave the railway station following signage for trams. After passing through the barriers, turn right onto Station Street, turn left at Jury's onto London Road. At the roundabout, bear right onto Lower Parliament Street (A6008) towards MachineMart, turn right at MachineMart onto Pennyfoot Street. Enter second building on the right (white with green stripes) with black Innovation Building sign outside (postcode NG1 1GF) - about 12 minutes' walk.
There is no car parking for visitors at the venue, BioCity.
Instead the nearest car park (run by the city council) is immediately behind the Innovation Centre, Motorpoint Arena. Further information about charges may be found here, and you should buy your ticket from the machine. Here is a site plan showing the car park location.
Cloud Cars offers an eco-friendly car service. The entire fleet is of environmentally-friendly hybrid cars, which run on a combination of electricity and petrol, significantly reducing emissions. Book via this weblink or by telephone on 01158 244244. Card only, fixed-price fares.
DG Cars are open 24 hours a day. Book via this weblink or by telephone on 01159 500500 and 01159 607607.
You may take a bus from East Midlands airport to Nottingham railway station, or you may take a train from East Midlands Parkway railway station to Nottingham.
DG Cars offer airport transfers which may be booked online via this weblink or by telephone on 01159 500500 and 01159 607607.
This symposium is organised by the RSC BMCS (Biological and Medicinal Chemistry Sector) and the RSC CICAG (Chemical Information and Computer Applications Group).
We are grateful to Sygnature Discovery for their generous sponsorship of this event.
Chris Swain (chair), Cambridge MedChem Consulting
Jonathan Goodman, University of Cambridge
Mihiro Sunose, Sygnature Discovery
Mary Wheldon, University of Dundee
Maggi Churchouse, 3 East Barn, Market Weston Road, Thelnetham, Diss IP22 1JJ, UK
Telephone: +44 (0)1359 221004
To contact the secretariat, please send an e-mail.
Registration is now closed - fully booked
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