Twenty Years of the Rule of Five


Wednesday, 20th November 2019


Sygnature Discovery, BioCity, Nottingham, UK



Registration is open


Twitter hashtag - #RuleofFive2019


Downloads and Links
Online registration - to pay by card
Registration form - for payment by bank transfer or cheque


First announcement

Abstract template - closing dates are 30th June (oral) and 6th October (poster)

Bursary application form - closing date is 4th October

Directions to the venue

RSC website


It has been over twenty years since Lipinski published his work determining the properties of drug molecules associated with good solubility and permeability. Since then, there have been a number of additions and expansions to these “rules”. There has also been keen interest in the application of these guidelines in the drug discovery process and how these apply to new emerging chemical structures such as macrocycles.

This symposium will bring together researchers from a number of different areas of drug discovery and will provide a historical overview of the use of Lipinski’s rules, as well as looking to the future and how we use these rules in the changing drug compound landscape.


Features of the Meeting

  • Historical look at the use of the Rule of Five

  • New parameters used in drug discovery

  • Look forward to the next 20 years

  • Panel discussions in each session

  • Plenary speakers, poster session, drinks reception

Confirmed Speakers

Elisabetta Chiarparin, AstraZeneca, UK
Phil Cox, AbbVie, USA

The rule of five and the pursuit of compound quality

Paul Leeson, Consultant, UK

Jean-Louis Reymond, University of Bern, Switzerland

Molecule properties: how relevant are aromatic and aliphatic descriptors?

Tim Ritchie, Consultant, UK

Michael Shultz, Novartis, USA


Who should attend

This meeting is of interest to scientists of any level of experience from academia and industry.

Call for Short Talk and Poster Abstracts

Applications for oral and poster presentations are invited. Short talks within the theme of historical use of the Rule of Five or looking forward and beyond the Rule of Five are welcomed. Posters will be displayed throughout the day. The closing dates are 30th June (oral) and 6th October 2019 (posters).


Please download an abstract template here.


Registration and Bursaries

Online registration - to pay be card (not yet available)
Registration form - to pay by cheque or bank transfer

£120 RSC member
£165 Non-member
  £50 RSC student* member
  £80 Student* non-member
* Student is undergraduate or post-graduate, not post-doc
Member is a paid-up member of the RSC. A late fee of £30 will apply to payments received from 19th October onwards.

A number of RSC-BMCS and RSC-CICAG student bursaries are available up to a value of £250, to support registration, travel and accommodation costs for PhD and post-doctoral applicants studying at European academic institutions. The closing date for bursary applications is 4th October.

Please download a bursary application form here.


Delegate Pack Inserts

Delegate pack inserts may be booked at £150, comprising no more than two pages of A4 fixed together.


Cancellation Policy
In the event of cancellation before 6th November, 80% of the fee paid will be refunded. Cancellations must be received in writing. Refunds will not be possible from that date although substitutions are possible at any time.

In the unlikely event of cancellation of the meeting, fees paid will be refunded in full.  Registration acknowledgements will be sent within two weeks.

Venue and Travel
Address:  Innovation Building, Sygnature Discovery, BioCity, Pennyfoot Street, Nottingham NG1 1GF

Travel:  East Midlands airport is just 20 minutes away, and regular trains run direct from London (journey time two hours).  Sygnature Discovery is just over half-a-mile from the railway station. 


Leave the railway station following signage for trams. After passing through the barriers, turn right onto Station Street, turn left at Jury's onto London Road. At the roundabout, bear right onto Lower Parliament Street (A6008) towards MachineMart, turn right at MachineMart onto Pennyfoot Street. Enter second building on the right (white with green stripes) with black Innovation Building sign outside (postcode NG1 1GF) - about 12 minutes' walk.

This symposium is organised by the RSC BMCS (Biological and Medicinal Chemistry Sector) and the RSC CICAG (Chemical Information and Computer Applications Group). 



We are grateful to Sygnature Discovery for their generous sponsorship of this event.



Organising Committee
Chris Swain (chair), Cambridge MedChem Consulting
Jonathan Goodman, University of Cambridge
Mihiro Sunose, Sygnature Discovery
Mary Wheldon, University of Dundee


Secretariat Contact
Maggi Churchouse, 3 East Barn, Market Weston Road, Thelnetham, Diss IP22 1JJ, UK
Telephone: +44 (0)1359 221004


To contact the secretariat, please send an e-mail.


Registration is open



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