Kinase 2021:
9th RSC / SCI symposium on kinase inhibitor design

 

Wednesday & Thursday, 14th & 15th April 2021

(two afternoon sessions)

A virtual event

 

Registration is open

and will close at 12.00 GMT on Monday, 12th April

 

Twitter hashtag - #Kinase21

 

 

Downloads and Links

Online registration - for payment by card

Registration form - to receive an invoice for settlement by bank transfer

 

Third announcement

 

RSC special offer on affiliate membership - follow this link to see below

Link to the BMCS's COVID-19 statement

 

RSC website

SCI website

 

Synopsis

With more than 49 FDA-approved small molecules, the field of kinase inhibition continues to attract significant investment from the drug discovery and development community. The 9th RSC/SCI symposium on kinases will encompass plenary lectures on emergent topics and case studies of ongoing programmes as well as successful past programmes.

 

This event will be hosted on Zoom.

 

Programme Themes
This event will bring together industrial and academic experts representing many of the leading institutions in kinase drug discovery, to discuss a selection of new and emerging topics within the fields of kinase therapeutics for oncology and non-oncology therapies, and foster discussions within the wider industry through networking and industrial exhibitions.

 

Who should attend?
This event is aimed at all scientists interested in furthering their knowledge of kinases. It will also have wider appeal to members of the drug discovery community eager to understand how enzyme inhibitor programmes are approached and executed across the pharmaceutical industry. 

 

Programme

Note:  All timings are UK time (BST).

 

Wednesday, 14th April 2021

 

Session 1

 

Session co-chairs:  Mihiro Sunose, Sygnature Discovery, and Pascal Savy, Charles River, UK

14.00Opening remarks
14.05

The shape-shifting protein kinases
Peter Parker, Francis Crick Institute, UK

14.35

Use of NanoLuc®-derived bioluminescent tools for live-cell target engagement and PROTAC-mediated degradation of kinases

Craig Malcolm, Promega, UK

14.40

Design and evaluation of novel heterocyclic cysteine targeting covalent warheads and their application in identification of selective irreversible kinase inhibitors
Kirsten McAulay, CRUK Beatson Institute, UK

15.10

Refreshment break

 

Session 2

Session co-chairs:  Douglas Williamson, Vernalis Research, and Ray Finlay, AstraZeneca, UK

15.25

Discovery of potent and selective Nuak1 inhibitors

Karine G Poullennec, UCB Biopharma, Belgium

15.55

Prep HPLC from Teledyne ISCO: Taking the hard work out of method development with our focused gradient generator

Nicola Brown, Teledyne ISCO, USA

16.00

Fragment-derived, selective and orally-active inhibitors of DYRK1A and DYRK1B
Lee Walmsley, Vernalis Research, UK

16.30

Closing remarks

 

Thursday, 15th April

 

Session 3

 

Session co-chairs:  John Harris, CJH Consultants, and Hannah Woodward, University College London, UK

14.00Opening remarks
14.05

Protein degradation of kinases with PROTACs: a route to differentiated medicines?
John Harling, GlaxoSmithKline, UK

14.35

Enhanced kinase discovery and validation using TMT® proteomics
Ian Pike, Proteome Sciences, UK

14.40

Discovery of potent TTBK1 inhibitors that lower tau phosphorylation in vivo for the treatment of Alzheimer’s disease
Toma Halkina, Biogen, USA

15.10

Refreshment break

 

Session 4

Session co-chairs:  John Cumming, F Hoffman-La Roche, Switzerland, and Sarah Major, Evotec, UK

15.25

Exploiting the kinase conformational repertoire for allosteric regulation of IRE1α kinase-endoribonuclease
Ian Collins, The Institute of Cancer Research, UK

15.55

Activate Scientific: chemistry services for drug discovery

Declan Wolverson, Activate Scientific, UK

16.00

Highly selective DDR1 Inhibitors from efficient screening and structure-guided design
Bernd Kuhn, F Hoffmann-La Roche, Switzerland

16.30

Closing remarks

 

Registration

Registration is open

Online registration - for payment by card

Registration form - to receive an invoice for settlement by bank transfer

 

Registration fees are:

  £75 RSC or SCI member*
£100 Non-member
  £35 RSC or SCI student** member
  £50 Student** non-member

*   Member is paid-up member of the RSC or SCI.
**  Student is undergraduate or post-graduate, not post-doc, and does not apply to students in paid employment.
 

Cancellation Policy

In the event of cancellation by 28th March 2021, 80% of the fee paid will be refunded. Cancellations must be received in writing. Refunds will not be possible after that date although substitutions are possible at any time. In the unlikely event of cancellation of the meeting, fees paid will be refunded in full.
 

Exhibition

We are offering two Exhibition Opportunities for our valued supporters.

 

Exhibitor Sponsorship Package
Your name and weblink on our event webpage
Your logo in the rolling slides shown at the event and a web-linked logo in the electronic delegate handbook
An A4 promotional page in the electronic delegate handbook
Charge is £150  (excludes delegate registration)

Exhibitor Speaker Package
All features in the above Exhibitor Sponsorship Package, plus:
- a pre-recorded speaker slot of 5 minutes max, 5 slides max, to be shown at a time to be determined

Charge is £250  (excludes delegate registration)
Full booked - sorry

 

Confirmed Exhibitor Speakers, with weblinks
Activate Scientific

Promega

Proteome Sciences

Teledyne ISCO

 

Confirmed Exhibitor Sponsors, with weblinks
Apex Molecular

Aurelia Biosciences

BioAscent Discovery

BLD Pharmatech

Carna Biosciences

Liverpool ChiroChem

Pharmacelera

Reach Separations

Reaction Biology

Selvita

SVI Phosphocellulose Paper

 

RSC Special Offer on Membership

 

 

We know that not everyone in the audience is a member of the Royal Society of Chemistry and there may be several reasons for this, but right now the RSC are offering free Affiliate membership to anyone who attends one of our online events. If you have ever considered joining but haven’t got around to it, or are not sure what you could get out of being a member, then maybe now is the time to sign up as an Affiliate for free and try it out.

Affiliate membership does not need a degree transcript or CV, simply go to
rsc.li/affiliate and use the discount code IG100 to join - you can then become a member of our Interest Group, the BMCS, and keep up to date with all of our events and activities!

Affiliate membership offers:
- Free membership of one Interest Group*
- Depending on where you are in the world, automatic membership of an RSC Local Section - - Ten free RSC journal article downloads a year, and 35% off RSC books
- Online access to Chemistry World
- Access to careers resources and webinars, and discounts for accredited training courses
- Support from the Chemists’ Community Fund
- Discounts on travel, insurance, lifestyle and publications.
* You may wish to choose the BMCS (Biological and Medicinal Chemistry Sector)!

 

Sponsors

We are grateful to our confirmed sponsors

 

 

 

 

 

 


 

 

 

 

 

We are grateful to our supporters below:

 

 

 

 

 

Organising Committee

John CummingF Hoffmann-La Roche
Ray FinlayAstraZeneca
John HarrisCJH Consultants
Pascal Savy (chair)Charles River
Mihiro SunoseSygnature Discovery
Douglas Williamson (treasurer)Vernalis Research

     

Secretariat Contact

Maggi Churchouse Events, 3 East Barn, Market Weston Road, Thelnetham, Diss IP22 1JJ, UK

E-mail Maggi Churchouse

Telephone: +44 (0)1359 221004

 

Registration is open

 

Link to return to the RSC BMCS index page