2nd RSC Anglo-Nordic Medicinal Chemistry Symposium


Tuesday-Friday, 11th-14th June 2019

Hotel Comwell Borupgaard, Snekkersten, Denmark


Registration is open


Twitter hashtag - #ANMC2019


Downloads and Links

Registration form - for payment by bank transfer

Online registration - for payment by card


Second announcement and call for posters

First announcement

Poster abstract template - closing date is 30th April 2019


Venue website (showing location)

National travel information website

RSC website



This 2.5 day symposium follows on from the very successful inaugural meeting held in 2017 containing high quality international speakers from industry and academia on topics of Medicinal Chemistry and related enabling technologies. Organised by the Biological and Medicinal Chemistry Sector of the Royal Society of Chemistry, together with Nordic affiliates, the meeting promises to be an exciting and invigorating gathering packed with fantastic opportunities to disseminate knowledge and expand networks.


Programme Themes and Features

The scientific programme will feature themed lectures, focusing on medicinal chemistry and related technologies and disciplines across a range of drug targets and modalities. A distinguishing feature of this symposium is the collegiate style which encourages an atmosphere of information sharing and learning.

The event will include first rate lectures, poster session, trade exhibition, ample networking opportunities, welcome buffet on Tuesday, exceptional location, venue and accommodation.


Who should attend

Medicinal chemists at all career stages. Scientists with an interest in drug discovery or new technologies that can be applied to the drug discovery process.


Call for Posters

The call for posters is open, and papers are invited for poster presentation. The closing date is 30th April 2019, and some posters will be selected for flash oral presentation.


Download an abstract template here.


The call for oral abstracts closed on 31st October 2018.


Full Programme - draft, subject to change


Tuesday, 11th June


Welcome reception, registration, and buffet dinner




Wednesday, 12th June





Session 1 - Translational Regulation

Session chair - Malin Lemurell, AstraZeneca, Sweden


Opening remarks

Kevin Dack, LEO Pharma, Denmark and Member of the Organising Committee, UK


Keynote:  Translating RNA sequence into lead small molecule medicines

Matthew Disney, Scripps Research, USA


Optimising PROTACs towards the clinic: turning promises of low dose and long duration into reality

Ian Smith, GlaxoSmithKline, UK


Refreshments, exhibition and posters


Discovery and characterization of highly potent and selective allosteric USP7 inhibitors
Colin O'Dowd, Almac Discovery, UK


Rewriting the (tran)script: discovery of Risdiplam

Hasane Ratni, Roche, Switzerland


Lunch, exhibition and posters




Flash poster presentations

Session chairs - Kevin Dack, LEO Pharma, Denmark, and

Morten Jørgensen, Lundbeck, Denmark


Dedicated poster session, refreshments



Session 2 - Enabling Science and Technologies I

Session chair - Adrian Hall, UCB, Belgium


Late stage functionalisation of drug candidates using PolyCYPs® enzymes

Frank Scheffler, Hypha Discovery, UK


Can a computer design a drug?
John Cumming, pRED, F Hoffmann-La Roche, Switzerland


Identification of nanomolar inhibitor of RuvBL1/2 from DNA-encoded small molecule library
Iolanda Micco, Vipergen ApS, Denmark





Thursday, 13th June



Session 3 - Enabling Science and Technologies II

Session chair - Morten Jørgensen, Lundbeck, Denmark

09.00Keynote:  Prodrug strategies in medicinal chemistry
Jarkko Rautio, University of Eastern Finland, Finland


Structurally enabled discovery of innovative Calcitonin Gene-Related Peptide (CGRP) receptor antagonists
Steve Watson, Heptares, UK


Refreshments, exhibition and posters


Lowering lipophilicity by adding carbon - building bridges to improve physicochemical properties of drug molecules
Sébastien Degorce, AstraZeneca, UK


HIV nucleoside reverse transcriptase translocation inhibitors to enable extended duration dosing

Izzat Raheem, MSD, USA


Lunch, exhibition and posters




Session 4 - Drug Design Disclosures I

Session chair - Kevin Dack, LEO Pharma, Denmark


Discovery of GLPG2451, a novel potentiator for the treatment of cystic fibrosis
Hans Kelgtermans, Galapagos, Belgium


The Lundbeck approach to FBDD in the CNS drug space - from weak fragments to the PDE1 inhibitor development candidate

Mauro Marigo, Lundbeck, Denmark


Discovery of novel pyrido[2,3-b]pyrazine based small molecule pan-Fibroblast Growth Factor Receptor (FGFR) inhibitors and optimization into a potential clinical candidate
Patrick Angibaud, Janssen, France


Refreshments, exhibition and posters


Discovery of AZD5718, a novel 5-lipoxygenase activating protein (FLAP) inhibitor currently in Ph2 for treatment of Coronary Artery Disease (CAD)
Daniel Pettersen, AstraZeneca, Sweden


Identification of a novel oxadiazole RORg antagonist – a balancing act
Morten Dahl Sørensen, LEO Pharma, Denmark



Conference dinner


Friday, 14th June



Session 5 - Drug Design Disclosures II

Session chair - Sharan Bagal, AstraZeneca, UK


Target validation with chemical probes: reproducing pharmacology and safety aspects of the phenotype of Rorc-deficient mice with RORC2 inverse agonists in rats

Samuel Hintermann, Novartis, Switzerland


Discovery of the TYK2 selective inhibitor PF-6826647 for the treatment of Crohn’s disease, and other autoimmune conditions
Brian Gerstenberger, Pfizer Inc, USA


Refreshments, exhibition and posters


Discovery of the oral LTC4S inhibitor AZD9898 as a new treatment for asthma
Lena Ripa, AstraZeneca, Sweden


Discovery of H3B-8800, a novel, orally bioavailable, small molecule, splice modulator

Andrew Cook, H3 Biomedicine, USA


Resetting the antibacterial arms race: LepB as a novel gram negative target

James Crawford, Genentech, USA


Closing remarks

Sharan Bagal, AstraZeneca and Chair of the Organising Committee, UK


Lunch and depart


Registration, Fees, and Bursaries

Registration form - for payment by bank transfer

Online registration - for payment by card


The previous meeting was very popular and oversubscribed such that capacity has been increased to 140 attendees for 2019. Discounted rates are offered to RSC members and limited student bursaries are available.

Registration fees include the Tuesday evening welcome buffet.

Early rates for payments received by 22nd March
£525 RSC member
£605 Non-member
£400 RSC student* member
£440 Student* non-member

Standard rates for payments received between 23rd March and 10th May
£575 RSC member
£655 Non-member
£450 RSC student* member
£490 Student* non-member

Late rates for payments received from 11th May onwards
£55   Late payment fee was added to the above standard rates

* Student is undergraduate or post-graduate, not post-doc, and does not apply to students in paid employment.
Member is paid-up member of the RSC.

Some student bursaries were available for this meeting (funded by the RSC-BMCS). The closing date for applications was 16th April. 



Exhibition stands are priced at £1,100, and this fee includes for one full delegate with access to the technical programme.


Each exhibitor stand will comprise a space measuring 1.5 metres wide with electricity and a table measuring 1.5 m wide x 0.75 m deep x 0.72 m high.


Delegate pack inserts may be booked at £275 (sponsor to supply), comprising no more than two pages of A4 fixed together.



The accommodation and dinners package is priced at £585, and  comprises:
- three nights’ bed and breakfast accommodation at the conference Hotel Comwell Borupgaard (from Tuesday to Thursday inclusive)
- three-course dinner with drinks on Wednesday
- conference dinner with drinks on Thursday
It is advisable to book this at the time of registration.


Venue and Travel

Address:  Hotel Comwell Borupgaard, Nørrevej 80, Snekkersten 3070, Denmark


Travel (with guide prices - please check for yourself): 

By train:  55 minutes from Copenhagen airport/railway station to Snekkersten.   Cost £10-£17

By taxi:  45 minutes from Copenhagen airport/railway station to Snekkersten.  Cost £95-£100

By bus and train:  1h 50m from Copenhagen airport/railway station to Snekkersten.  Cost £7-£20



A location map may be found here

A map with travel modes and charges from Copenhagen station may be found here.

National travel information website



We are grateful to our confirmed sponsors, AstraZeneca, LEO Pharma, Lundbeck, and Vipergen for their valued support. Additional sponsors are sought.



Organising Committee

Sharan Bagal (chair)AstraZeneca, UK
Kevin N DackLEO Pharma, DK
Adrian HallUCB, BE
Morten JørgensenLundbeck, DK
Malin LemurellAstraZeneca, SE


Secretariat Contact

Maggi Churchouse Events, 3 East Barn, Market Weston Road, Thelnetham, Diss IP22 1JJ, UK


Telephone: +44 (0)1359 221004


Registration is open