Downloads and Links Second announcement and call for posters First announcement Flash presentation programme Catalogue of posters Twitter link to actual posters - no Twitter account is required RSC special offer on affiliate membership - follow this link to see below Link to the BMCS's COVID-19 statement RSC website |
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Synopsis Synthesis is at the heart of drug discovery and development. The industry has increasingly demanded higher quality clinical candidates and has sought to exploit less druggable biological targets. Densely functionalised small molecules with a high degree of synthetic complexity are often the result of these demands. Successful programmes therefore require the application of innovative synthesis in all stages of discovery and development. The medicinal chemist’s toolbox is also enhanced by the introduction of novel bioisosteres, often made available only through the application of new synthetic methods. This symposium aimed to celebrate the crucial role of synthesis in the success of drug discovery and development. GoToWebinar - hosting symposium Grapevine - networking and meeting poster presenters, speakers, exhibitors and other registered delegates (open 11.00-13.00 and16.00-18.00 both days) Twitter - hosting actual posters |
Programme Themes and Features The three main themes of the symposium were: • Innovative synthesis facilitating candidate discovery • Novel bioisosteres and methodology applicable to drug discovery • Overcoming challenges of scale-up and process scale chemistry |
Who should attend Chemists from industry and academia, including synthetic, medicinal and process chemists. |
Call for Posters Applications were invited for poster presentation. Posters were displayed throughout both days and applicants were asked if they wished to provide a two-minute flash oral presentation when submitting their abstracts. The abstract closing date was 29th January. A prize was awarded to the poster judged to be the best, a £100 RSC book voucher, kindly provided by "RSC Medicinal Chemistry Journal". The winner was Angus McMillan of ETH Zürich, with his poster entitled "Sp3-rich virtual library construction and automated hit synthesis". Well done, Angus! Flash presentation programme Catalogue of posters Twitter link to actual posters - no Twitter account is required |
Programme Note: All timings were UK time (GMT). Where the presentation title appears in this colour, you may view a .pdf of the presentation slides. Monday, 22nd March | 13.00 | Opening remarks Duncan Hay, Vertex | | Session chair: Martin Swarbrick, Cancer Research UK | 13.05 | Innovative synthetic methods and their application to the discovery of ATAD2 inhibitors Carine Guérot, AstraZeneca | 13.45 | Discovery, application and conformational bias of aryl 3-oxabicyclo[4.1.0]heptanes, non-nitrogen containing bioisosteres of N-aryl morpholines Heather Hobbs and Luke Green, GlaxoSmithKline | 14.25 | Bioisosteric replacements and scale-up challenges in drug discovery Thomas Fessard, SpiroChem | 15.05 | Refreshment break | | Session chair: Nadia Ahmad, Charles River | 15.20 | Flash poster presentations (part 1) - download programme here | 15.20 | Second-generation tricyclic pyrimido-pyrrolo-oxazine mTOR inhibitor with predicted blood–brain barrier permeability Chiara Borsari, University of Basel, Switzerland (P01) | 15.22 | Synthesis of α-methyl-β- (N-piperidyl)propanoic acid hydrazide derivatives and their pharmacological activity Dmitriy Berillo, University of Brighton, UK (P02) | 15.24 | Catalytic α-C–H functionalisation of primary amines Alexander Cresswell, University of Bath, UK (P03) | 15.2 | Development of inhibitors for DNA gyrase as novel antibacterials Kyle Orritt, University of Leeds, UK (P10) | 15.28 | Studies towards the synthesis of functionalised bi-aryl drug candidates as ubiquitin ligase inhibitors Joshua Hall, University of East Anglia, UK (P11) | 15.30 | Synthesis of new DHEA 17-spiro-cyclopropyl derivatives with neurotrophic, neuroprotective and anti-inflammatory activity Alessia Latorrata, National Hellenic Research Foundation, Greece (P16) | 15.35 | Development and application of facile and flexible 2+2+2 cyclo-trimerisation methodology and its impact on two lead identification programmes Simon Peace, GlaxoSmithKline | 16.15 | New synthetic chemistry for the exploration of 3-D pharmaceutical space Peter O'Brien, University of York | 16.55 | Closing remarks | 17.00 | Networking with exhibitors, poster presenters and speakers You were encouraged to join this networking session | 17.45 | Close | Tuesday, 23rd March | 13.00 | Opening remarks Duncan Hay, Vertex | | Session chair: Katherine Jones, GlaxoSmithKline | 13.05 | Synthesis of new chemical motifs as design options for drug discovery James Bull, Imperial College London | 13.45 | Glucose responsive insulin – synthesis enabling discovery and development Paul Bulger, MSD | 14.25 | Modern organic synthesis in the discovery of chemical probes for new targets Paul Brennan, Structural Genomics Consortium | 15.05 | Refreshment break | | Session chair: Andrew Williams, Honorary Chairman of the RSC BMCS | 15.20 | Flash poster presentations (part 2) - download programme here | 15.20 | Chiral resolution of anti-cancer β-lactam racemic derivatives of Combretastatin A-4 using column chromatography Eavan McLoughlin, Trinity College, Dublin, Ireland (P05) | 15.22 | Sp3-rich virtual library construction and automated hit synthesis Angus McMillan, ETH Zürich, Switzerland (P06) | 15.24 | Development of small molecule notum inhibitors to potentiate Wnt signalling Hannah Woodward, University College London, UK (P09) | 15.26 | Discovery of novel pyrimidine-based inhibitors of Respiratory Syncytial Virus fusion protein Matthew Barrett, ReViral Ltd, UK (P13) | 15.28 | New cannabinoid CB2 receptor modulators in the treatment of microglial-mediated neuroinflammation Rebecca Ferrisi, University of Pisa, Italy (P14( | 15.30 | Novel continuous flow methodologies for the fast and effective generation of a new HBV inhibitor series Justine Raymond, Institute of Chemical Research of Catalonia (ICIQ), Spain (P15) | 15.35 | Sp3-rich cyclic hydrazine frameworks for drug discovery Mike Shipman, University of Warwick | 16.15 | A 3-way BET to scale up a trans-disubstituted dihydrobenzofuran active bromodomain inhibitor Catherine Alder, GlaxoSmithKline | 16.55 | Closing remarks | 17.00 | Networking with exhibitors, poster presenters and speakers You were encouraged to join this networking session | 17.45 | Close |
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Registration Registration closed at 12.00 GMT on Thursday, 18th March Registration fees were: £50 RSC member* £75 Non-member £25 RSC student** member £37 Student** non-member * Member is paid-up member of the RSC. ** Student is undergraduate or post-graduate, not post-doc, and does not apply to students in paid employment. |
Cancellation Policy In the event of cancellation before 6th March 2021, 80% of the fee paid will be refunded. Cancellations must be received in writing. Refunds will not be possible from 7th March onwards, although substitutions are possible at any time.
In the unlikely event of cancellation of the meeting, fees paid will be refunded in full. |
Exhibitor Opportunities We were offering two alternative packages to our valued supporters. Exhibitor Sponsorship Package Charge of £60 and comprising: - your name and weblink on this event webpage - your logo in the rolling slides shown at the event and a web-linked logo in the electronic delegate handbook - an A4 promotional page in the electronic delegate handbook No delegate registration is included
Speaker Sponsorship Package Charge of £120 and comprising: - all features in the above Exhibitor Sponsorship Package, plus: - a promotional slide shown before one talk or poster session - your organisation’s name mentioned by the Session Chair prior to the presenter’s introduction No delegate registration was included. Confirmed Speaker Sponsors, with weblinks Apex Molecular BioAscent Discovery BLD Pharmatech Enantia Charnwood Molecular Liverpool ChiroChem Confirmed Exhibitor Sponsors, with weblinks Biotage AB, from Sweden Enamine ICB Nuvisan Reach Separations |
RSC Special Offer on Membership 
We know that not everyone in the audience is a member of the Royal Society of Chemistry and there may be several reasons for this, but right now the RSC are offering free Affiliate membership to anyone who attends one of our online events. If you have ever considered joining but haven’t got around to it, or are not sure what you could get out of being a member, then maybe now is the time to sign up as an Affiliate for free and try it out.
Affiliate membership does not need a degree transcript or CV, simply go to rsc.li/affiliate and use the discount code IG100 to join - you can then become a member of our Interest Group, the BMCS, and keep up to date with all of our events and activities!
Affiliate membership offers: - Free membership of one Interest Group* - Depending on where you are in the world, automatic membership of an RSC Local Section - Ten free RSC journal article downloads a year, and 35% off RSC books - Online access to Chemistry World - Access to careers resources and webinars, and discounts for accredited training courses - Support from the Chemists’ Community Fund - Discounts on travel, insurance, lifestyle and publications. * You may wish to choose the BMCS (Biological and Medicinal Chemistry Sector)! |
Sponsors We are grateful to the organisations below for sponsoring this event. 



We are grateful to our supporters below: 
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Organising Committee Nadia Ahmad, Charles River Duncan Hay (chair), Vertex Martin Swarbrick (treasurer), Cancer Research UK Andrew Williams, Hon Chairman, RSC BMCS |
Secretariat Contact Maggi Churchouse, 3 East Barn, Market Weston Road, Thelnetham, Diss IP22 1JJ, UK Telephone: +44 (0)1359 221004 E-mail: maggi@maggichurchouseevents.co.uk |
Image credit The image is derived from “Gilbert Chemistry Set” (https://tinyurl.com/y4smxepk) by Steve Lodefink, under CC BY (https://creativecommons.org/licenses/by/2.0) |
Registration is now closed Link to return to the RSC BMCS index page |