Downloads and Links Online registration - for payment by card Registration form - for payment by bank transfer or cheque Second announcement and call for posters First announcement Poster abstract template - closing date is 29th January RSC special offer on affiliate membership - follow this link to see below Link to the BMCS's COVID-19 statement RSC website |
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Synopsis Synthesis is at the heart of drug discovery and development. The industry has increasingly demanded higher quality clinical candidates and has sought to exploit less druggable biological targets. Densely functionalised small molecules with a high degree of synthetic complexity are often the result of these demands. Successful programmes therefore require the application of innovative synthesis in all stages of discovery and development. The medicinal chemist’s toolbox is also enhanced by the introduction of novel bioisosteres, often made available only through the application of new synthetic methods. This symposium aims to celebrate the crucial role of synthesis in the success of drug discovery and development. |
Programme Themes and Features The three main themes of the symposium will be: • Innovative synthesis facilitating candidate discovery • Novel bioisosteres and methodology applicable to drug discovery • Overcoming challenges of scale-up and process scale chemistry |
Who should attend Chemists from industry and academia, including synthetic, medicinal and process chemists. |
Call for Posters Applications are invited for poster presentation. Posters will be displayed throughout both days and applicants are asked if they wish to provide a two-minute flash oral presentation when submitting their abstracts. The abstract closing date is 29th January. Please download a template here. |
Programme Monday, 22nd March | 13.00 | Opening remarks Duncan Hay, Vertex | | Session chair: Martin Swarbrick, Cancer Research UK | 13.05 | Innovative synthetic methods and their application to the discovery of ATAD2 inhibitors Carine Guérot, AstraZeneca | 13.45 | Discovery, application and conformational bias of aryl 3-oxabicyclo[4.1.0]heptanes, non-nitrogen containing bioisosteres of N-aryl morpholines Heather Hobbs, GlaxoSmithKline | 14.25 | Bioisosteric replacements and scale-up challenges in drug discovery Thomas Fessard, SpiroChem | 15.05 | Refreshment break | | Session chair: Nadia Ahmad, Charles River | 15.20 | Flash poster presentations (part 1) | 15.35 | Development and application of facile and flexible 2+2+2 cyclo-trimerisation methodology and its impact on two lead identification programmes Simon Peace, GlaxoSmithKline | 16.15 | New synthetic chemistry for the exploration of 3-D pharmaceutical space Peter O'Brien, University of York | 16.55 | Closing remarks | 17.00 | Close | Tuesday, 23rd March | 13.00 | Opening remarks Duncan Hay, Vertex | | Session chair: Katherine Jones, GlaxoSmithKline | 13.05 | Synthesis of new chemical motifs as design options for drug discovery James Bull, Imperial College London | 13.45 | Glucose responsive insulin – synthesis enabling discovery and development Paul Bulger, MSD | 14.25 | Modern organic synthesis in the discovery of chemical probes for new targets Paul Brennan, Structural Genomics Consortium | 15.05 | Refreshment break | | Session chair: Andrew Williams, Honorary Chairman of the RSC BMCS | 15.20 | Flash poster presentations (part 2) | 15.35 | Sp3-rich cyclic hydrazine frameworks for drug discovery Mike Shipman, University of Warwick | 16.15 | A 3-way BET to scale up a trans-disubstituted dihydrobenzofuran active bromodomain inhibitor Catherine Alder, GlaxoSmithKline | 16.55 | Closing remarks | 17.00 | Close |
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Registration Registration is open and fees include attendance at both afternoon sessions. Online registration - for payment by card Registration form - for payment by bank transfer or cheque £60 RSC member* £100 Non-member £25 RSC student** member £37 Student** non-member * Member is paid-up member of the RSC. ** Student is undergraduate or post-graduate, not post-doc, and does not apply to students in paid employment. |
Cancellation Policy In the event of cancellation before 6th March 2021, 80% of the fee paid will be refunded. Cancellations must be received in writing. Refunds will not be possible from 7th March onwards, although substitutions are possible at any time.
In the unlikely event of cancellation of the meeting, fees paid will be refunded in full. |
Exhibitor Opportunities We are offering two alternative packages to our valued supporters. Exhibitor Sponsorship Package Charge of £60 and comprising: - your name and weblink on this event webpage - your logo in the rolling slides shown at the event and a web-linked logo in the electronic delegate handbook - an A4 promotional page in the electronic delegate handbook No delegate registration is included
Speaker Sponsorship Package Charge of £120 and comprising: - all features in the above Exhibitor Sponsorship Package, plus: - a promotional slide shown before one talk or poster session - your organisation’s name mentioned by the Session Chair prior to the presenter’s introduction No delegate registration is included. Confirmed Exhibitor Supporters, with weblinks Apex Molecular (speaker sponsorship) BioAscent Discovery (speaker sponsorship) BLD Pharmatech (speaker sponsorship) Charnwood Molecular (speaker sponsorship)Liverpool ChiroChem (speaker sponsorship) Reach Separations (exhibitor sponsorship) |
RSC Special Offer on Membership 
We know that not everyone in the audience is a member of the Royal Society of Chemistry and there may be several reasons for this, but right now the RSC are offering free Affiliate membership to anyone who attends one of our online events. If you have ever considered joining but haven’t got around to it, or are not sure what you could get out of being a member, then maybe now is the time to sign up as an Affiliate for free and try it out.
Affiliate membership does not need a degree transcript or CV, simply go to rsc.li/affiliate and use the discount code IG100 to join - you can then become a member of our Interest Group, the BMCS, and keep up to date with all of our events and activities!
Affiliate membership offers: - Free membership of one Interest Group* - Depending on where you are in the world, automatic membership of an RSC Local Section - - Ten free RSC journal article downloads a year, and 35% off RSC books - Online access to Chemistry World - Access to careers resources and webinars, and discounts for accredited training courses - Support from the Chemists’ Community Fund - Discounts on travel, insurance, lifestyle and publications. * You may wish to choose the BMCS (Biological and Medicinal Chemistry Sector)! |
Sponsors We are grateful to the organisations below for sponsoring this event. 


We are grateful to our supporters below: 
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Organising Committee Nadia Ahmad, Charles River Duncan Hay (chair), Vertex Martin Swarbrick (treasurer), Cancer Research UK Andrew Williams, Hon Chairman, RSC BMCS |
Secretariat Contact Maggi Churchouse, 3 East Barn, Market Weston Road, Thelnetham, Diss IP22 1JJ, UK Telephone: +44 (0)1359 221004 E-mail: maggi@maggichurchouseevents.co.uk |
Image credit The image is derived from “Gilbert Chemistry Set” (https://tinyurl.com/y4smxepk) by Steve Lodefink, under CC BY (https://creativecommons.org/licenses/by/2.0) |
Registration is open Link to return to the RSC BMCS index page |