2nd Nucleosides and Nucleotides:

synthetic and biological chemistry


Tuesday, 20th April 2021



A virtual event

Registration is now closed

Registration closed at 12.00 BST on Friday, 16th April



Twitter hashtag #Nucleosides21



Downloads and Links

Third announcement

Posters page - to view actual posters

Delegate handbook - password-protected, for registered delegates only


RSC special offer on affiliate membership - follow this link to see below

Link to the BMCS's COVID-19 statement


RSC website


Nucleosides are key structures for current drug development and have established roles as antivirals and anticancer agents. Their (poly)phosphorylated nucleotide counterparts are critical tools for chemical biology and sequencing technologies. In recent years, nucleotides have also become fundamental building blocks for the preparation of altered genes and coding systems for synthetic biology. This meeting sought to explore and celebrate the chemistry that drives the development of modern nucleoside and nucleotide chemistry. It brought together scientists who work at the interfaces of synthetic and biological chemistry to deliver new tools and insights for biology, and new leads for drug development.


This event was hosted on GoToWebinar, and networking was hosted on Grapevine Today.


Features of the Meeting
• Synthetic methodologies for the preparation of nucleosides, nucleotides and related molecules
• Applications for nucleosides and nucleotides as medicines
• Applications of nucleosides and nucleotides as tools for chemical biology and synthetic biology
• Invited speakers, virtual poster session and exhibition



Where presentation titles are highlighted in blue, you may find a

link to the speakers' slides.






Session chair:   David Hodgson, University of Durham, UK


Systems chemistry: on the origins of nucleic acids
Matthew Powner, University College London, UK


Functional-GNA nucleosides: synthesis, biological activity and applications in Xeno-nucleic acid chemistry
Konrad Kowalski, University of Łódź, Poland

10.50Quality nucleosides and nucleotides for your research needs
Renate van Well, Biosynth Carbosynth, UK


Polymerase synthesis of base-modified nucleic acids for diagnostics, imaging and chemical biology

Michal Hocek, Academy of Sciences of the Czech Republic


Refreshment break, exhibition and posters networking



Session chair:   Ben Andrews, GlaxoSmithKline, UK


Chemoenzymatic synthesis of NDP sugars as chemical biology tools to explore the GDP-D-mannose dehydrogenase from Pseudomonas aeruginosa
Gavin Miller, Keele University, UK


BLD - supporting the development of modern nucleoside and nucleotide chemistry

Andrew Fraser, BLD Pharmatech, UK


The making and breaking of nucleoside polyphosphates using polyphosphate kinases
Jenny Andexer
, University of Freiburg, Germany


Lunch break, exhibition and posters networking



Session chair:  Glenn Burley, University of Strathclyde, UK


Discovery of 3’-deoxy modified purine nucleoside analogues as potent leads for the treatment of sleeping sickness
Fabian Hulpia, Ghent University, Belgium


TUC-1: a novel ferronucleoside with anticancer activity in pancreatic ductal adenocarcinoma (PDAC)
Marium Rana, University of Birmingham, UK


Quality synthesis and manufacture of nucleosides and nucleotides

Neil Sim, High Force Research, UK


An introduction to oligonucleotide therapeutics
Ben Andrews, GlaxoSmithKline, UK


Refreshment break, exhibition and posters networking



Session chair:  Joe Sweeney, University of Lancaster, UK


Eco-friendly approaches for the synthesis of dinucleotides and related compounds
Béatrice Roy, University of Montpellier, France

16.15Harnessing the power and potential of palladium catalysis for the synthesis of chemically modified nucleosides
Yogesh Sanghvi, Rasayan Inc, USA
16.45Postsynthetic installation of functionalized nucleosides in DNA and RNA strands
Saulius Klimašauskas, Vilnius University, Lithuania
17.15Diversifying biocatalytic C-alkylation by mapping S-adenosyl methionine cofactor space
Glenn Burley, University of Strathclyde, UK
17.45Poster prize-giving





Weblink to Posters page. 

The full listing of posters may also be found in this file.


Abstracts were invited for poster presentation, and the submission deadline was 10th March 2021. 


The poster prize-winners were:

1st prize

Alexandre Hofer (P07), University of Cambridge
Selective chemical functionalization of N6-methyladenine in DNA

Joint Runners-up
Simeon D Draganov (P04), Imperial College London
Development and validation of novel nucleotide prodrugs for studying the post-translational modification ADP-ribosylation in living cells


Chiara Figazzolo (P06), Institut Pasteur
Synthesis of a vancomycin-modified uridine to be included in aptamers


We are offering two alternative packages to our valued supporters.

Exhibitor Sponsorship Package
Charge of £75 and comprising:
- your name and weblink on this event webpage
- your logo in the rolling slides shown at the event and a web-linked logo in the electronic delegate handbook
- an A4 promotional page in the electronic delegate handbook
No delegate registration is included

Exhibitor Speaker Package 
sorry, fully booked
Charge of £150 and comprising:
- all features in the above Exhibitor Sponsorship Package, plus:
- plus a 5-minute, 5-slide presentation within main programme (limited to 4)
No delegate registration is included.

Confirmed Exhibitor Packages, with weblinks


Exhibitor Speakers

Biosynth Carbosynth

BLD Pharmatech

High Force Research


Exhibitor Sponsors

Concept Life Sciences

Glen Research reagents distributed in the UK by Cambio



Registration is now closed (closed at 12.00 BST on Friday, 16th April)

£50 RSC member*
£75 Non-member
£25 RSC student** member
£37 Student** non-member

* Member is a paid-up member of the RSC.
** Student is undergraduate or post-graduate, not post-doc


Cancellation Policy

In the event of cancellation before 6th April 2021, 80% of the fee paid will be refunded.  Cancellations must be received in writing.  Refunds will not be possible after that date although substitutions are possible at any time.


RSC Special Offer on Membership



We know that not everyone in the audience is a member of the Royal Society of Chemistry and there may be several reasons for this, but right now the RSC are offering free Affiliate membership to anyone who attends one of our online events. If you have ever considered joining but haven’t got around to it, or are not sure what you could get out of being a member, then maybe now is the time to sign up as an Affiliate for free and try it out.

Affiliate membership does not need a degree transcript or CV, simply go to
rsc.li/affiliate and use the discount code IG100 to join - you can then become a member of our Interest Group, the BMCS, and keep up to date with all of our events and activities!

Affiliate membership offers:
- Free membership of one Interest Group*
- Depending on where you are in the world, automatic membership of an RSC Local Section - - Ten free RSC journal article downloads a year, and 35% off RSC books
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- Support from the Chemists’ Community Fund
- Discounts on travel, insurance, lifestyle and publications.
* You may wish to choose the BMCS (Biological and Medicinal Chemistry Sector)!


Sponsors are encouraged to support this second event. Please contact the secretariat for further information.


We are grateful to our confirmed sponsors:


We are grateful to our confirmed supporters:




This event is organised jointly by the RSC BMCS and the RSC NAG

(Royal Society of Chemistry's Biological and Medicinal Chemistry Sector,

and Royal Society of Chemistry's Nucleic Acids Group)


Organising Committee
David Hodgson (co-chairman), University of Durham and RSC NAG
Joe Sweeney (co-chairman and treasurer), Lancaster University and RSC BMCS


Secretariat Contact
RSC BMCS Secretariat

Mrs Maggi Churchouse
Telephone: +44 (0)1359 221004
E-mail:  maggi@maggichurchouseevents.co.uk


Registration is now closed

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