6th RSC / SCI symposium

on Ion Channels

as Therapeutic Targets

Monday-Tuesday, 24th-25th February 2020

Wellcome Genome Campus Conference Centre, Cambridge, UK

 

Registration is open

 

Twitter hashtag - #IonChannels20

 

Downloads and Links

Online registration - to pay by card

Registration form - for payment by bank transfer or cheque
 

Second announcement

First announcement

Poster abstract template - closing date is 15th November

 

Venue location map

Venue directions

 

RSC website

SCI website

Synopsis

Ion channels are important targets for therapeutic intervention due to their extensive roles in human physiology and the pathophysiology of disease. Many successful drugs targeting this gene family have been discovered for diseases such as hypertension, epilepsy and neuropathic pain.

This symposium, the 6th in an ongoing series, will showcase the most recent advances to aid the design of new ion channel therapeutics and promote interaction between scientists with a shared interest in the field of ion channel drug discovery.

Who should attend

Scientists from industry and academia interested in the therapeutic potential of ion channels. The organising committee particularly welcomes attendance and participation of students working in the field of ion channel research.

Features

• Medicinal chemistry case studies of ion channels as therapeutic targets
• Advances in structure determination techniques and successful structure determinations
of key ion channels
• Novel pharmacology and target validation
• Emerging technologies for targeting, assaying and modulating ion channel targets
• Plenary speakers, poster sessions, trade exhibition, on-site accommodation and dinner

Call for Papers
Abstracts are invited for poster presentation, and the closing date is 15th November. Posters will be displayed throughout the meeting, there will be optional flash oral presentations, and a dedicated poster session on Monday evening.  The closing date for oral abstract submissions was 21st June.

 

Please download an abstract template here.

Confirmed Speakers

Keynote Presentation

Ion channel drug discovery - fading star or shining light?

Martin Gosling, Enterprise Therapeutics, UK
 

Human GABAA receptor structures and signalling mechanisms
Radu Aricescu, MRC Laboratory of Molecular Biology, UK

 

Understanding and manipulating the Piezo1 force sensor in health and disease

David J Beech, University of Leeds, UK

 

The discovery and optimisation of triazine-oxadiazoles as inhibitors of NaV1.7

Jonathan Bentley, Evotec, UK

 

Understanding potent small-molecule modulation of TRPC1/4/5 channels

Robin Bon, University of Leeds, UK
 

Latest drug developments in the field of ion channels

Andrea Brüggemann, Nanion Technologies, Germany
 

Understanding the causes of genetic diseases through structural biology of human ion channels

Liz Carpenter, Structural Genomics Consortium, University of Oxford, UK

 

The discovery of potentiators of the calcium-activated chloride channel, TMEM16A

Henry Danahay, Enterprise Therapeutics, UK
 

Discovery of small molecule scaffolds that improve stability and restore function to the F508del Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) anion channel
Phil Kym, AbbVie, USA
 

Provisional: NGlu2B NAMs
Mike Letavic, Janssen R&D, USA

 

Application of physiological multidimensional SAR (MuDiSAR) for identification of novel TASK1 inhibitors by uHTS

Thomas Müller, Bayer

 

Please take off your coat: how naked ions ensure rapid and selective potassium channel permeation

Ulrich Zachariae, University of Dundee, UK

Registration Fees
Online registration - to pay by card

Registration form - for payment by bank transfer or cheque
Registration fees include the conference dinner at the Wellcome Trust on Monday evening.

Up to 29th November
£300 Member of the RSC or SCI
£350 Non-member
£135 Student* member of the RSC or SCI
£160 Student* non-member

From 30th November to 22nd January
£330 Member of the RSC or SCI
£390 Non-member
£150 Student* member of the RSC or SCI
£170 Student* non-member

From 23rd January
£50 Late booking fee (for payments received by the Secretariat after 22nd January)

* Student is an undergraduate or postgraduate, not post-doc

Cancellation Policy
In the event of cancellation before 10th February 2020, 80% of the fee paid will be refunded. Cancellations must be received in writing. Refunds will not be possible from 10th February although substitutions are possible at any time.

In the unlikely event of cancellation of the meeting, fees paid will be refunded in full. Registration acknowledgements will be sent within two weeks.

Bursaries
Discounted rates will be offered to RSC and SCI members, and some student bursaries will be available.   The closing date for applications has yet to be agreed.

Exhibitors
There will be a relevant trade exhibition.  Stand space will measure 3 m wide x 2 m deep, and will include a table, chair, electrical and wi-fi access.   The charge is:

 

£900    Exhibition stand including one full

           delegate with conference dinner

£250    Exhibition stand staff, including conference dinner

           no access to technical sessions)
 

The option for delegate pack inserts is also available, charged at £250 for a maximum of two sheets of A4 fixed together (sponsor supplies).

Dinner
The conference dinner will be held at the Wellcome Trust and is included in the registration fee.

Venue and Travel
Wellcome Genome Campus Conference Centre, Hinxton, Cambridge CB10 1RQ, UK.


By air: Stansted airport is 20 minutes’ drive, London City and Luton are 60 minutes, and Heathrow and Gatwick are 90 minutes.
  Additional travel information may be found here, and you may download a directional map here.

Accommodation

Accommodation is available at the conference venue, and may be booked direct.  All bedrooms are in Mulberry and Willow Courts.

 

The charge for an en suite room, single occupancy, is £102 including breakfast.  Bedrooms are available on Sunday and Monday, 23rd and 24th February (limited availability).

 

To book accommodation, please follow this weblink and note that the booking code is RSC18327.

 

As a conference delegate staying on Campus, you may even make use of their free bicycle hire initiative - follow this link.

Alternative hotel options in Cambridge and nearby may be found on the Hotel Info website here.

Organising Committee

Karl Collins

 

Bayer

Brian Cox

 

University of Sussex

Ged Giblin Giblin Consultancy
Sarah Major Charnwood Molecular (chair)

Nigel Swain

 

Sosei Heptares

Jason Tierney

 

Top Tier Consultancy

Sponsors

Sponsors are encouraged to support this well-respected event.  We are most grateful to our sponsor below:

 

 

To contact the secretariat, please e-mail Maggi - maggi@maggichurchouseevents.co.uk

Registration is open

 

 

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