5th RSC / DMDG / DMG

New Perspectives in DMPK

 

 

Tuesday-Wednesday, 4th-5th May 2021

Liverpool Medical Institution & Conference Centre, Liverpool, UK

 

 

Registration is not yet open

(formerly planned for 5th-6th May 2020)

 

Twitter hashtag #DMPK21

  

Downloads and Links

Poster abstract template - closing date is 2nd April 2021

Bursary application form - closing date is 14th April 2021


Directions to the venue

RSC website

DMDG website

 

Notes regarding postponement to 2021

We will provide new dates for registration, abstract submission and bursary application later in the year, when a formal announcement will be made.

 

Coronavirus Disease (COVID-19)

 

Statement from RSC BMCS Committee

18th March 2020
 

With the ongoing Coronavirus situation and increasing requirements for social distancing, the RSC BMCS Committee has taken the decision to cancel all solely or jointly arranged meetings up to and including GPCRs on 21st-23rd September 2020. It is hoped that planned 2020 meetings can take place on similar dates in 2021.

 

Please check www.rsc.org/bmcs and our social media outlets (Twitter @RSC_BMCS, LinkedIn, Facebook and Instagram @RSCBMCS, YouTube) for any updates. It is our policy that 100% refunds be given to registered delegates. We would, however, ask for your patience for these to be processed. Thank you for your understanding.

 

For current information regarding the virus, please refer to the websites of the UK Government and Public Health England, or the World Health Organisation. 

 

Synopsis
Members from across the DMPK research community are encouraged to join colleagues from across academic, industrial, and third-sector institutions and contribute to the ongoing discussion, evolution and application of DMPK in various scenarios.

The event programme will incorporate sessions themed around the following key topics:
- DMPK and Drug Discovery
- DMPK and Drug Safety
- Analytical and Computational Advances in DMPK

In addition, the programme also includes a keynote talk, ‘flash’ presentations from early career researchers, and opportunities for open debate and discussion.
 

Programme Themes
Session 1 - DMPK and Drug Discovery
Understanding chemical and biological interactions that mediate pharmacological and toxicological effects of drugs and their metabolites is an important part of the drug discovery picture. In this session, we will showcase some of the more recent developments in our collective understanding of

Session 2 - DMPK and Drug Safety
This session will provide an interdisciplinary platform for academics and scientists to present and discuss the most recent innovations and practical challenges in the fields of DMPK to address drug safety, and particularly the emerging safety issues relating to biotherapeutics. It will include presentations on transporters associated with drug-induced tissue injury, new in vitro models for mechanistic toxicity assessment, and recent developments in predicting intrinsic immunogenicity of drugs.

Session 3 - Analytical and Computational Advances in DMPK
Advances in analytical and computational performance, and the availability of new instruments, methods, and approaches commonly unlocks new knowledge about compound stability, reactivity, interaction, and disposition. This session will showcase recent developments in bioanalytical science and computational modelling that have provided fresh insight and understanding in DMPK.
 

Who should attend
Medicinal chemists, drug discovery scientists, pharmacologists, toxicologists, DMPK scientists – from academia, industry, and third sector institutions.

 

Call for Poster Submissions
The call for poster abstracts is open.  The closing date for poster abstract submission is 2nd April 2021.  To submit an abstract, please download and submit this template.

 

Programme - draft
 

Tuesday, 5th May
12.00Registration and lunch
13.00Welcome
Toby Athersuch, Imperial College London, UK
Joint Organising Committee (RSC-BMCS, DMDG, DMG)
13.10Keynote presentationMetabolism of strained rings: tales of the unexpected
Martin Hayes, AstraZeneca, SE

 

Flash Poster Presentations

14.00

Blood-brain barrier “on-a-chip” model for testing drug permeability into the brain (poster)
Chloë Whitehouse, University of Nottingham, UK

14.05

Presentation title to be confirmed (poster)

Presenter to be confirmed

14.10

Presentation title to be confirmed (poster)

Presenter to be confirmed

 

DMPK and Drug Discovery I – Chemistry and Mechanisms

14.15

Presentation title to be confirmed
Andrew Stachulski, University of Liverpool, UK

14.55

Presentation title to be confirmed

Presenter to be confirmed

15.35

Refreshments, exhibition and posters

 

 

DMPK and Drug Discovery II – Application and Strategy

16.15Is drug lipidation a new paradigm in DMPK?
John Sanderson, Durham University, UK
16.55

Presentation title to be confirmed

Presenter to be confirmed

 

Close

 

18.00

Drinks reception

19.00

Conference dinner (optional)

22.30

Close

 

Wednesday, 6th May

 

Drug Discovery and Drug Safety I – Small Molecules

09.00

Acyl glucuronides in perspective
Ian Wilson, Imperial College London, UK

09.40

Presentation title to be confirmed
Speaker to be confirmed

10.20

Refreshments, exhibition and posters

 

Drug Discovery and Drug Safety II - Biologics

10.40

Presentation title to be confirmed
Speaker to be confirmed

11.20

Optimising proteolysis targeting chimeras (PROTACs) for oral drug delivery: A drug metabolism and pharmacokinetics perspective
Andy Pike, AstraZeneca Ltd, UK

12.00

Presentation title to be confirmed
Speaker to be confirmed

12.40

Lunch, exhibition and posters

 

Analytical and Computational Advances in DMPK

14.00

Prediction of DILI using 3D liver microtissues
Lynsey Chatham, Cyprotex Discovery Ltd, UK

14.40

One-stop metabolite shop: employing multiple tools for accessing drug metabolites
Julia Shanu-Wilson, Hypha Discovery Ltd, UK

15.20

Finding the metabolite needle in a matrix haystack
James O’Neill, Charles River Laboratories, UK

16.00

Closing remarks

 

Registration, Students and Bursaries
Registration is not yet open

 

Early rates for payments received by 29th January
£200 RSC or DMDG member*
£300 Non-member
£100 RSC or DMDG student** member
£150 Student** non-member

Standard rates for payments received between 30th January and 2nd April
£300 RSC or DMDG member*
£400 Non-member
£145 RSC or DMDG student** member
£205 Student** non-member

Late rates for payments received from 3rd April onwards
£40 Late payment fee to be added to the above standard rates

 

£54 Conference dinner (optional extra)

* Member is paid-up member of the RSC or DMDG.
** Student is undergraduate or post-graduate, not post-doc, and does not apply to students in paid employment.

Discounted rates are available for RSC and DMDG student members, and some student bursaries are also available. The closing date is 14th April. Please download an application form here.

 

RSC membership webpage

DMDG membership webpage

 

Exhibition Opportunities
The exhibition is now fully booked - sorry.

 

Exhibition opportunities were available for this meeting, and the exhibition package charge of £750 included exhibition stand space and one full delegate.   Trade stand staff with no access to the technical sessions were charged at £200.

 

The exhibition package comprises:

- a space measuring 1.8 m wide x 1 m deep

- a table measuring approximately 1.8 m wide x 0.6 m deep - optional

- no chair - due space restrictions

- electrical access if required - please indicate

- wi-fi access.

 

IMPORTANT:  In view of the stand space available, you are kindly asked to bring pull-up roller panels (banner stands) rather than the large curved pop-up stands.   You may opt to have no table or electrical access if preferred.

 

Those companies wishing to have a trade stand were encouraged to apply early to avoid disappointment as space was limited to five stands. 

 

Cancellation Policy
For cancellations received in writing by the Secretariat, 80% of the fee paid will be refunded for notifications received before 20th April. No refunds will be made for cancellations received from 20th April  onwards, although substitutions will be possible at any time. In the unlikely event of our cancelling the event, we will refund the registration fees paid in full.

 

Venue and Travel
The symposium will be held at the LMI Conference Centre, Liverpool Medical Institution, 114 Mount Pleasant, Liverpool L3 5SR, UK. Travel information may be found here.
 

Conference Dinner
The conference dinner will be held on the evening of Tuesday, 4th May, and this is available to book as a chargeable optional extra at £54.

 

Delegates are encouraged to book the dinner at the time of registration if required as places will be limited.

 

The dinner will be held at the 60 Hope Street Restaurant, six minutes' walk from the conference venue.

 

Sponsors
Sponsorship opportunities are available for this meeting, including delegate pack inserts (£250) and conference social events.  Please contact the secretariat to sponsor this event.

 

We are grateful to our confirmed sponsors below:

 

 

 

 

We are grateful to EFMC  for supporting this event

 

 

 

Organising Committee
Toby Athersuch (chairman), Imperial College London and the DMG
Xiaoli Meng, University of Liverpool

Dean Naisbitt, University of Liverpool

Mark Seymour, Covance and DMDG
Andrew Stachulski (treasurer), University of Liverpool and RSC-BMCS
 

Secretariat Contact
Maggi Churchouse, 3 East Barn, Market Weston Road, Thelnetham, Diss IP22 1JJ, UK
Telephone: +44 (0)1359 221004
E-mail:  maggi@maggichurchouseevents.co.uk

 

Registration is not yet open

Link to return to the RSC BMCS index page