Macrocycles 2018

3rd RSC BMCS Medicinal Chemistry Symposium

on Macrocycles

 

Monday-Tuesday, 8th-9th October 2018

GlaxoSmithKline, Stevenage, UK

 

 

Registration is open

 

Downloads and Links

Online registration - for payment by card
Registration form - for payment by bank transfer or cheque

 

Third announcement

Second announcement

First announcement

 

Venue directions

 

Travel bookings - please check this document for your own bookings

 

Accommodation booking link via InCorporate Venues - for Holiday Inn Stevenage and for Holiday Inn Express Stevenage  -  release date was 7th September, although the link will continue to offer best available rates for any latecomers.

 

Accommodation suggestions

RSC website

 

Synopsis

The objective of this symposium is to promote scientific interaction between scientists with a shared interest in the field of Macrocycles. This area is responsible for a growing number of therapeutic approaches and development candidates, all of which go ‘beyond the rule-of–five’. As a researcher in this field, come along to hear about the latest advances and also to share in some of the secrets of discovering therapeutic agents which go beyond Lipinski’s rules.

 

Programme

Monday, 8th October

10.00

Registration and refreshments

10.30

Welcome address

Chris Swain, Chairman of the Organising Committee, and Cambridge MedChem Consulting, UK

 

Session 1:  Peptides and Peptide-like Scaffolds

Session chair:  Brian Cox, University of Sussex, UK

10.30

Highly potent and selective tumour targeting bicyclic peptides - a novel approach to cancer therapy
Paul Beswick, Bicycle Therapeutics

11.05

Keynote  A RaPID way to discover bioactive macrocyclic peptides
Hiroaki Suga, University of Tokyo

12.00

Enriching chemical space with macrocycles to drug undruggable targets
David Spring, University of Cambridge

12.35

Total synthesis and SAR of macrocyclic peptides and depsipeptides

A Ganesan, University of East Anglia

13.10

Lunch, posters, exhibition

 

 

Session 2:  Case Studies (part I)

Session chair:  Sanja Kostrun, Fidelta, Croatia

14.10

CNS active macrocycles, potential treatments for neurodegeneration
Dave Selwood, University College London

14.50

Fragment approach towards the design of natural product macrocycle analogs
Didier Roche, Edelris

15.30

Refreshments, posters, exhibition

16.00

The discovery of a potent and orally bioavailable macrocyclic Cyclophilin inhibitor based on the structural simplification of Sanglifherin A
Vicky Steadman, Selcia

 

16.40

 

Flash Poster Presentation Session

Session chair:  Dave Alker, Chemistry Recruitment Consultant, UK

The flash programme may be viewed via this link

17.00

Drinks reception and posters

18.00

Close

 

Tuesday, 9th October

 

Session 3:  Properties and Methodologies

Session chair:  Vicky Steadman, Selcia, UK

09.30

The role of solution conformations in structure-based drug design of macrocycles

Elisabetta Chiarparin, AstraZeneca

10.10

Recent advances in orally available macrocycles
Gordon Saxty, Fidelta

10.50

Refreshments, posters and exhibition

11.20

In silico macrocycle design with the Schrödinger suite
Dan Sindhikara, Schrodinger

12.00

New methodology for the efficient synthesis of small macrocyclic peptides
Mike Shipman, University of Warwick

12.40

Lunch, posters and exhibition

 

 

Session 4:  Case Studies (part II)

Session chair:  A Ganesan, University of East Anglia, UK

13.40

New compounds of the OMPTA class displaying potent activity against a broad panel of Gram-negative bacteria

Anatol Luther, Polyphor

14.20

Design of high affinity macrocyclic inhibitors of B-cell lymphoma 6 (BCL6)
Bill McCoull, AstraZeneca

15.00

Keynote  Eribulin macrocyclization design concepts
Francis Fang, Eisai

15.55

Refreshments

16.10

Close

 

Call for Abstracts

Applications for poster presentations were welcome. Posters will be displayed throughout the meeting and applicants should indicate whether they wish to be considered for a flash oral presentation when submitting an abstract (two minutes, single slide).
 

The closing date for abstract submission was 8th August.   (The closing date for oral abstract submission was 28th February.)

 

Registration and Discounted Student Rates

Online registration - for payment by card
Registration form - for payment by bank transfer or cheque

 

Early rates for payments received by 5th July
£160 RSC member
£240 Non-member

Standard rates for payments received between 6th July and 6th September
£190 RSC member
£280 Non-member

Student rates for payments received by 6th September
  £60 RSC student* member
£105 Student* non-member

Late rates for payments received from 7th September onwards
£40 Late payment fee to be added to the above standard rates

* Student is undergraduate or post-graduate, not post-doc, and does not apply to students in paid employment.
Member is a paid-up member of the RSC.
 

Bursaries

A number of RSC-BMCS student bursaries up to a value of £250, to support registration, travel and accommodation costs for PhD and post-doctoral applicants studying at European academic institutions. The closing date for bursary applications was 22nd August, and eleven RSC BMCS bursaries have been awarded.

 

Exhibition

There will be a relevant trade exhibition and the charge of £850 includes:

- stand space, table measuring 1.6 m wide x 0.8 m deep, chair, access to electricity and wi-fi (details to be provided)

- inclusion of a promotional page in the delegate handbook
- logo acknowledgement in the delegate handbook

- one full delegate with all catering.

The exhibition is now fully booked - sorry!

 

Delegate pack inserts may be booked at £250 - no more than two sheets of A4 fixed together.

 

Cancellation Policy

In the event of cancellation by 22nd September 2018, 80% of the fee paid will be refunded. Cancellations must be received in writing. Refunds will not be possible after that date although substitutions are possible at any time. In the unlikely event of cancellation of the meeting, fees paid will be refunded in full.
 

Sponsorship   

We are grateful to our confirmed sponsors, AstraZeneca and Fidelta.

Additional sponsors are sought.

 

  

 

    

 

 

We are grateful to EFMC and COMS for supporting this event

 

Venue and Travel

Address: GlaxoSmithKline, Gunnels Wood Road, Stevenage, SG1 2NY.  Venue directions are here.

Rail: Four trains per hour from London Kings Cross, journey time around 30 minutes. 

Road:  Located on the A1, there is ample parking available on site (registration number required). For satnav purposes, please use SG1 2FX.
Air: 12 miles from Luton airport, 35 miles from Heathrow airport, 35 miles from Stansted airport.
Coach: The conference will provide one coach trip per morning and evening between Stevenage and the venue. Gratis, first come first served.   Please refer to the next section, Coach Transport, for details.

 

Coach Transport

We have an arranged for coach transport as detailed below. This will be provided gratis, and you are advised to book your requirements at the time of registration, as the limited number of spaces will be allocated on a "first come, first served" basis.

Please review this listing to check your bookings are correct.

Monday, 8th October - morning
09.25 Bus-stop outside Matalan in Danestrete*, Stevenage
09.30 Stevenage railway station
09.45 Arrive GlaxoSmithKline, via security gatehouse

Monday, 8th October - evening
18.00 Depart GlaxoSmithKline
18.15 Stevenage railway station
18.20 Bus-stop outside Matalan in Danestrete*, Stevenage

Tuesday, 9th October - morning
08.50 Bus-stop outside Matalan in Danestrete*, Stevenage
08.55 Stevenage railway station
09.15 Arrive GlaxoSmithKline, via security gatehouse

Tuesday, 9th October – afternoon
16.10 Depart GlaxoSmithKline
16.25 Stevenage railway station
16.30 Bus-stop outside Matalan in Danestrete*, Stevenage
 

* Bus-stop outside Matalan in Danestrete is the pick-up/drop-off point for both the Holiday Inn Stevenage and the Holiday Inn Express Stevenage.

 

Accommodation

We have an arrangement with InCorporate Venues whereby you may book rooms at the Holiday Inn Stevenage and at the Holiday Inn Express Stevenage using this weblink.  You may cancel by midday on 7th September without financial penalty, and the release date was 7th September.  This weblink will continue to offer best available rates for any latecomers.
 

In addition, a list of accommodation suggestions may be found here.

 

Free coach transport (see above) will be provided between the venue and central Stevenage.

 

Organising Committee

Dave AlkerChemistry Recruitment Consultant
Brian CoxUniversity of Sussex
A GanesanUniversity of East Anglia (treasurer)
Sanja KostrunFidelta

Vicky Steadman

Selcia
Chris SwainCambridge MedChem Consulting (chairman)

     

Secretariat Contact

Maggi Churchouse Events, 3 East Barn, Market Weston Road, Thelnetham, Diss IP22 1JJ, UK

E-mail Maggi Churchouse to register an interest in this symposium.

Telephone: +44 (0)1359 221004

 

Registration is open