Kinase 2018:
towards new frontiers

8th RSC / SCI symposium on kinase inhibitor design

 

Monday-Tuesday, 14th-15th May 2018

Babraham Research Campus, Cambridge, UK

 

 

Registration is open

 

Downloads and Links

Online registration - for payment by card

Registration form - for payment by bank transfer or cheque

 

Second announcement

First announcement

Abstract template - closing date is 31st March

Bursary application form - closing date is 2nd April

 

Coach travel bookings - please check your requirements

Venue website

Venue location map

Travelodge Fourwentways online booking - available until 16th March

Accommodation suggestions

RSC website

SCI website

 

Synopsis

With more than 25 FDA-approved small molecules, the field of kinase inhibition continues to attract significant investment from the drug discovery and development community. The 8th RSC/SCI symposium on kinases will encompass case studies of ongoing programmes as well as successful past programmes. A range of topics including CNS kinase inhibitors, allosteric inhibitors and non-oral delivery methods will be covered, along with views and perspectives on the future of kinase inhibitor research.

 

Provisional Programme and Confirmed Speakers

(subject to change at the discretion of the Organising Committee)

 

Monday, 14th May
09:30Registration and refreshments
10:00Opening remarks
10:05Keynote presentation

Targeting PI3Ks in immunity, infection and cancer

Klaus Okkenhaug, University of Cambridge and Babraham Institute, UK

10:45

Discovery and development of a novel, immunosuppressive class of lipid kinase inhibitors able to prolong allogeneic organ engraftment

James Reuberson, UCB, UK

11:15Refreshments, exhibition and posters
11:45

Discovery of GDC-0077, a highly isoform selective inhibitor of PI3Kα that promotes selective degradation of mutant-p110α

Emily Hanan, Genentech, USA

12:20

Roger Griffin Memorial Lecture:  Inhibitors of the mitotic kinase MPS1:  discovery of an orally bioavailable preclinical development candidate

Julian Blagg, Institute of Cancer Research, UK

13:00Lunch, exhibition and posters
14:00

A potent and orally bioavailable ERK1/2 series identified through fragment screening which modulates the phosphorylation and catalytic activity of ERK1/2

Valerio Berdini, Astex Pharmaceuticals, UK

14:30

NVP‐LXS196, a novel PKC inhibitor for the treatment of uveal melanoma

Julien Papillon, Novartis Institutes for Biomedical Research, USA

15:00Reserved for late breaker
15:30Refreshments, exhibition and posters
16:00Flash poster presentations (session 1)
16:20

Identification of low clearance indole acid AMPK activators for the treatment of diabetic nephropathy

David Ebner, Pfizer, USA

16:55

New leads from old drugs: repurposing kinase inhibitor chemotypes for tropical diseases

Michael Pollastri, Northeastern University, USA

17:30Flash poster presentations (session 2)
17:50Network reception, exhibition and posters
19:00Conference dinner

 

Tuesday, 15th May

09:00

Strategy and tactics for the discovery of Kinase inhibitors for CNS targets. A Lundbeck perspective

Klaus Bæk Simonsen, Lundbeck

09:40

Building on the success of Osimertinib - achieving CNS exposure in oncology drug discovery

Nicola Colclough, AstraZeneca, UK

10:20Refreshments, exhibition and posters
10:50

Chemical strategies for activating PINK1, a protein kinase mutated in Parkinson’s disease

Youcef Mehellou, Cardiff School of Pharmacy and Pharmaceutical Sciences, UK

11:30

BBB penetrating tetracyclic TRK-selective inhibitor CH7057288: additional efficacy against brain metastasis in vivo model

Toshiya Ito, Chugai, Japan

12:10Interactive session
12:45Lunch, exhibition and posters
13:45

Discovery of the clinical candidate AZD1390: a high quality, potent and selective inhibitor of ATM kinase with the ability to cross the blood brain barrier

Thomas Hunt, AstraZeneca, UK

14:25

Structural mechanisms of regulation of the PI3Ks and related kinases

Roger Williams, MRC Laboratory of Molecular Biology, UK

15:05Closing remarks
15:10Close

 

Who should attend?
This event is aimed at all scientists interested in furthering their knowledge of kinases. It will also have wider appeal to members of the drug discovery community eager to understand how enzyme inhibitor programmes are approached and executed across the pharmaceutical industry.

 

Call for Posters

A poster session will take place at the end of Day 1. A one-page abstract should be submitted to the Secretariat by 31st March 2018. When submitting posters, delegates should indicate whether they would be prepared to give a single-slide summary of their poster in a formal presentation session that will take place on Day 1.

 

Download a poster abstract template here.   Closing date is 31st March.

 

Registration, Fees and Bursaries

Online registration - for payment by card

Registration form - for payment by bank transfer or cheque

 

Registration fees include Monday evening's dinner and free coach transport between Travelodge Fourwentways and Whittlesford Parkway railway station (one coach for each trip).

Early rates for payments received by 7th February
£269  RSC or SCI member
£325  Non-member
£140  RSC or SCI student* member
£159  Student* non-member

Standard rates for payments received between 8th February and 11th April
£324  RSC or SCI member
£392  Non-member
£168  RSC or SCI student* member
£196  Student* non-member

Late rates for payments received from 12th April onwards
£40  Late payment fee to be added to the above standard rates

* Student is undergraduate or post-graduate, not post-doc, and does not apply to students in paid employment.
Member is paid-up member of the RSC or SCI.

Some student bursaries are available, and the closing date is 2nd April.  Please download a bursary application form here.

 

Cancellation Policy

In the event of cancellation by 29th April 2018, 80% of the fee paid will be refunded. Cancellations must be received in writing. Refunds will not be possible after that date although substitutions are possible at any time. In the unlikely event of cancellation of the meeting, fees paid will be refunded in full.
 

Exhibition

There will be a relevant trade exhibition and the charge is £952.  This rate includes:

- stand space measuring 3 m wide x 2 m deep

- table measuring 1.5 m wide x 0.75 m deep x 0.73 m high

- access to electricity and wi-fi

- inclusion of a promotional slide to be played on rotation on the main screen during breaks
- logo acknowledgement in the delegate handbook

- one full delegate with all catering.

 

Delegate pack inserts may be booked at £250 - no more than two sheets of A4 fixed together.

 

Sponsorship

We are grateful to Evotec for their kind support.  Additional sponsors are encouraged to support this established event.

 

 

We are grateful to EFMC and COMS for supporting this event

 

Venue

Babraham Research Campus, Babraham Hall, Babraham, Cambridge, CB22 3AT UK.  There is ample free parking on site, and no parking permits are required.

 

Venue location map

Venue location weblink

 

Accommodation

A number of bedrooms have been held (via InCorporate Venues) at the Travelodge Fourwentways, and rooms may be booked online via this weblink, to obtain preferential rates which are priced at an average of £65.15 and £77.15 without and with breakfast respectively (for two nights' accommodation, Sunday and Monday).  Any unbooked bedrooms will be released at midday on 16th March, and cancellation is not possible thereafter.

 

Free coach transport (see below) will be provided between the venue and the Travelodge Fourwentways and Whittlesford Parkway railway station.    Other hotel suggestions may be found here.

 

Coach Transport

A coach has been booked to provide transport as outlined below.   This is provided gratis, and you are advised to book your requirements at the time of registration, as the limited number of spaces will be allocated on a "first come, first served" basis.   Timings are inserted below.

 

Please review this listing to check your bookings are correct.

 

Monday, 14th May - morning
08:40   Whittlesford Parkway railway station
08:50   Travelodge Cambridge Fourwentways
08:50   Babraham Research Campus

Monday, 14th May - evening
21:00   Babraham Research Campus
21:10   Travelodge Cambridge Fourwentways
21:20   Whittlesford Parkway railway station

Tuesday, 15th May - morning
08:25   Whittlesford Parkway railway station
08:35   Travelodge Cambridge Fourwentways
08:45   Babraham Research Campus

Tuesday, 15th May – afternoon
15:20    Babraham Research Campus
15:40    Whittlesford Parkway railway station
 

Organising Committee

John CummingRoche and SCI
John HarrisCJH Consultants
Pascal SavyCharles River and SCI
Mihiro SunoseSygnature and RSC

Martin Swarbrick

(chair)

Cancer Research UK and RSC
Andrew ThomasAstraZeneca

     

Secretariat Contact

Maggi Churchouse Events, 3 East Barn, Market Weston Road, Thelnetham, Diss IP22 1JJ, UK

E-mail Maggi Churchouse

Telephone: +44 (0)1359 221004

 

Registration is open