X-ray crystal structure of lovastatin bound to the CD11a I-domain of beta 2 integrin, LFA-1. PDB ID: 1CQP, Kallen et al., J. Mol. Biol. 1999, 292, 1–9

Integrin Targeted Drug Discovery


Thursday, 28th March 2019


Royal Society of Chemistry at Burlington House, London, UK



Registration is open


Downloads and Links
Online registration - to pay by card

Registration form - for payment by bank transfer or cheque


First announcement and call for abstracts

Abstract template - closing dates are 14th September (oral) and 31st December (poster)

Bursary application form - closing date is 7th February


Directions to the venue
RSC website


Integrins are heterodimeric, transmembrane receptors that function in cell adhesion and signalling. They are central to many disease states, including cancer, thrombosis, multiple sclerosis and Crohn’s disease. Integrin targeted therapeutics have been under investigation for some time, but few compounds have made it to / remained on the market due to side effects or lack of efficacy. Given the more recent structural insights, better understanding of downstream pathways, and potential application to a range of therapeutic areas, there has been a resurgence of interest in integrin inhibitors. This symposium will bring together researchers in this area to provide both a historical overview of the area and recent progress in designing the next generation of integrin inhibitors.


Who should attend
Scientists from industry and academia, including medicinal and computational chemists.


Features of the Meeting
Therapeutic targets for integrins
Targeting different RGD recognising integrins
Drug discovery, medicinal chemistry and structure-based design
Plenary speakers, poster session and trade exhibition

Call for Abstracts
Applications for oral and poster presentations are welcomed. Posters will be displayed throughout the day, and applicants will be asked if they would like to provide a two-minute flash oral presentation when submitting their abstract. Closing dates are 14th September 2018 for oral and 31st December 2018 for poster submissions.


Please download an abstract template here.


Confirmed Speakers

Prof Dermot Cox, Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland
Prof Daria Giacomini, Chemistry, University of Bologna
Dr Simon Goodman, formerly of Preclinical Oncology, Merck Serono
Prof Dr Horst Kessler, Chemistry, Technical University of Munich
Dr Helen Sheldrake, Cancer Therapeutics, University of Bradford


Registration and Bursaries
Online registration - to pay by card

Registration form - for payment by bank transfer or cheque

Registration for payments received by 24th February:
£120 RSC member
£150 Non-member
  £60 RSC student* member

Late rates for payments received from 25th February onwards:
£30 Late payment fee to be added to the above standard rates

Member is paid-up member of the RSC.

* Student is undergraduate or post-graduate (not post-doc), and does not apply to students in paid employment.
Member is paid-up member of the RSC.

Some student bursaries are available (to assist with registration fee, travel and accommodation).   Please download a bursary application form here, and note the closing date of 7th February.

A relevant trade exhibition will add value to the symposium.   The exhibition will be held in the same room as the catering (refreshments and lunch) and posters, and the exhibition package costs £530 and includes:
- chair and table
- electrical access and wi-fi access

- one full delegate attendance.
Those companies wishing to have a trade stand should register an interest with the secretariat. 


A delegate pack insert may be booked at £175 - no more than two pages of A4 fixed together.


Venue and Travel
The symposium will be held in the Science and Fish Rooms, Royal Society of Chemistry at Burlington House, Piccadilly, London, W1J 0BA, UK. Directions to venue.

Situated in central London, the RSC is easily accessible by public transport, and close to Green Park tube station.


Sponsors are encouraged to support this event, which will help us to offer inexpensive registration fees to young chemists.


Organising Committee
Richard Hatley, GlaxoSmithKline
Douglas Williamson, Vernalis (chairman)
Alison Woolford, Astex Pharmaceuticals

Secretariat Contact
Maggi Churchouse, 3 East Barn, Market Weston Road, Thelnetham, Diss IP22 1JJ, UK
Telephone: +44 (0)1359 221004
E-mail:  maggi@maggichurchouseevents.co.uk


To register an interest and to be notified when registration is open, please e-mail the Secretariat.


Registration is open



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