Downloads and Links
Online registration - for payment by card
Registration form - for payment by bank transfer or cheque
Second announcement and call for posters
First announcement and call for papers
Poster abstract template - closing date is 23rd April
Bursary application form - closing date is 9th April
Directions to the venue
DMDG website - to be uploaded
This meeting will provide a forum for the exchange of ideas between principal members of the DMPK (Drug Metabolism and Pharmacokinetics) research community. Keynote talks from thought leaders in industry and academia will provide global perspectives on how DMPK can bring value to the process on informing drug discovery and development. A range of ‘hot topics’ will be discussed, with a key theme being the central importance of understanding and harnessing underpinning chemical concepts. The emphasis will be on building dialogue between participants, who will range from experienced project/laboratory leaders to early-career researchers. There will be a balanced mix of oral and poster presentations, interactive Q&A sessions and networking opportunities throughout.
Who should attend
Medicinal chemists, drug discovery scientists, pharmacologists, toxicologists, DMPK scientists – from academia, industry, and third sector institutions.
Call for Posters
The call for posters is open, and abstracts are invited. The closing date is 23rd April. Some authors will be invited to deliver short flash oral presentations (maximum of ten minutes) - please indicate your preference on the template.
Download an abstract template here.
|Programme - draft, subject to change|
Monday, 21st May
Registration and lunch
Toby Athersuch, Imperial College London, UK
on behalf of the Joint Organising Committee (RSC-BMCS, DMDG, DMG)
Keynote presentation - The renaissance of biocatalysis in DMPK: lead diversification and metabolite synthesis
Douglas Spracklin, Pfizer, USA
Session 1 - Recent Highlights in DMPK Research
Session chair: Ian Wilson, Imperial College London / DMG
Avoiding collateral damage from magic bullets
Ted Parton, Mekinopsis Ltd, UK
Building on the success of osimertinib - achieving CNS exposure in oncology drug discovery
Nicola Colclough, AstraZeneca, UK
Understanding drug bioactivation in adverse drug reactions: a chemical and molecular perspective
Xaoli Meng, University of Liverpool , UK
Refreshments, exhibition and posters
Session 2 - Chemistry meets Large Molecules
Session chair: Mark Seymour, Covance / DMDG
Enzyme shielding in a soft organo-silica layer: biopharma applications
Yves Dudal, Inofea, Switzerland; and
Patrick Shahgaldian, FHNW University of Applied Sciences and Arts Northwestern Switzerland
|16.40||Presentation title and speaker to be confirmed|
New developments in stereodefined RNA therapeutics
Jörg Duschmalé, F Hoffmann-La Roche, Switzerland
Drinks reception, posters and exhibition
Conference dinner (optional), at the Keeper's House Restaurant at the Royal Academy of Arts (next door)
Tuesday, 22nd May
Session 3 - Reactive Metabolites
Session chair: Toby Athersuch, Imperial College London / DMG
Mechanistic and translational biomarkers as investigative tools for precision drug-induced liver injury risk assessment
Daniel Antoine, University of Edinburgh, UK
Carboxylic acid-containing drugs and glucuronide conjugates - is there a problem or is it guilt by association?
Ian Wilson, Imperial College London, UK
Towards the development of tests for the prediction of drug immunogenicity
Dean Naisbitt, University of Liverpool, UK
Flash poster presentations (up to 10 minutes each)
Lunch, posters and exhibition
Session 4 - Medicinal Chemistry and Metabolism
Session chair: Andrew Stachulski, University of Liverpool / RSC BMCS
Predicting routes, sites and products of metabolism by Cytochrome P450
Matthew Segall, Optibrium, UK
Lipophilicity – measurement, prediction and impact
Steve St-Gallay, Sygnature Discovery, UK
Leveraging humanized animal models to understand human drug disposition
Edna Choo, Genentech, USA
Registration, Students and Bursaries
Registration is open
Online registration - to pay by card
Registration form - to receive an invoice for settlement by bank transfer
Discounted rates are offered to members of the RSC and the DMDG. Please view the links below to join either of these bodies. Some student bursaries are also available, and the closing date is 9th April. Download a bursary application form here.
Registration fees are:
Early rates for payments received by 14th February
£200 RSC or DMDG member
£100 RSC or DMDG student* member
£140 Student* non-member
Standard rates for payments received from 15th February onwards
£300 RSC or DMDG member
£150 RSC or DMDG student* member
£200 Student* non-member
* Student is an undergraduate or post-graduate, not post-doc.
There is also an optional conference dinner (additional charge) for all on 21st May at the Keeper's House Restaurant (see below). This should be booked at the time of registration if required. The charge for the conference dinner is £60 and places are limited.
RSC membership webpage
DMDG membership webpage
Exhibition opportunities are available for this meeting, and there is the opportunity to sponsor delegate pack inserts at £250 and conference social events. Please contact the secretariat to register an interest in the latter.
Exhibition charges are:
£750 Exhibition trade stand, including one full delegate – fixed rate
£200 Additional trade stand staff – with no access to technical sessions
These charges exclude the optional conference dinner which should be booked in addition.
The exhibition package includes:
• Stand space for maximum of two 1 m wide roller panels
• One table measuring 0.8 m deep x 1.6 m wide x 0.725 m high (optional)
• Inclusion of a promotional slide to be played on rotation on the main screen during breaks
• Logo acknowledgement in the delegate handbook
Those companies wishing to have a trade stand should apply early to avoid disappointment as space is limited.
For cancellations received in writing by the Secretariat, 80% of the fee paid will be refunded for notifications received before 6th May. No refunds will be made for cancellations received from 7th May onwards, although substitutions are possible at any time. In the unlikely event of our cancelling the event, we will refund the registration fees paid in full.
|Venue and Travel|
The symposium will be held at the Royal Society of Chemistry at Burlington House, Piccadilly, London, W1J 0BA, UK. Travel information may be found here.
The conference dinner will be held on the evening of Monday, 21st May, and this may booked as an optional extra - charge £60.
The dinner will be held at the Keeper's House Restaurant at the Royal Academy of Arts, next door to Burlington House, the conference venue.
Sponsorship opportunities are available for this meeting, and there are opportunities to sponsor delegate pack inserts and conference social events. Please contact the secretariat for further details.
We are grateful to EFMC and COMS for supporting this event
Toby Athersuch (chairman), Imperial College London and the DMG
Mark Seymour, Covance and the DMDG
Andrew Stachulski, University of Liverpool and RSC-BMCS
Ian Wilson, Imperial College London and the DMG
Maggi Churchouse, 3 East Barn, Market Weston Road, Thelnetham, Diss IP22 1JJ, UK
Telephone: +44 (0)1359 221004
To register an interest and to be notified when registration is open, please e-mail the Secretariat.
Registration is open
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